Cell cycle independent expression of immediate early gene 3 results in a G 1 and G 2 arrest in MCMV - infected cells Running title : MCMV and cell cycle
نویسندگان
چکیده
* corresponding authors 15 Christian Hagemeier, MD PhD Lüder Wiebusch, PhD Ziegelstr. 5-9 Ziegelstr. 5-9 D-10117 Berlin D-10117 Berlin Tel: + 49 30 450 566041 Tel: + 49 30 450 566157 Fax: + 49 30 450 566913 Fax: + 49 30 450 566913 20 e-mail: [email protected] e-mail: [email protected] AC EP TE D Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.01212-08 JVI Accepts, published online ahead of print on 30 July 2008
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The 89,000-Mr murine cytomegalovirus immediate-early protein stimulates c-fos expression and cellular DNA synthesis.
The immediate-early (IE) genes of murine cytomegalovirus (MCMV) are expressed in the absence of prior viral protein synthesis and regulate the transcription of MCMV early genes. The effect of MCMV IE genes on growth induction was studied. Different plasmids containing MCMV IE genes were microinjected into arrested NIH 3T3 mouse fibroblasts. Plasmids containing the ieI gene coding for the 89,000...
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